Product Name : Gabexate mesylate
CAS#: 56974-61-9
|
Appearance |
White crystals or crystalline powder; it is very soluble in water, freely soluble in ethanol, and practially insoluble in diethyl ether. |
|
PH |
4.5~5.5 |
|
Melting point |
90 ~ 93℃ |
|
Heavy metals |
≤10 ppm |
|
Arsenic |
≤2ppm |
|
Loss on drying |
≤ 0.3% |
|
Residue on ignition |
≤ 0.1% |
|
Assay |
≥98.0% |
Gabexate is a kind of non-peptide protein inhibitor, which can inhibit the activities of trypsin, jigging release enzyme, fibrinolytic enzyme, thrombin and other proteases, so as to prevent the pathophysiological changes caused by these enzymes. In experimental acute pancreatitis, it can inhibit the activated trypsin and reduce the pancreatic injury. Meanwhile, the activity of serum amylase, lipase and the increase of urea nitrogen are also significantly improved. It can be used for the treatment of acute mild (edematous) pancreatitis, and also for the auxiliary treatment of acute hemorrhagic necrotizing pancreatitis.
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